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KMID : 0616120090400010001
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 1 p.1 ~ p.5
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Antioxidant and Antidiabetic Effects of Various Sections of Astragalus membranaceus
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Yin Yu
Heo Seong-Il
Wang Myeong-Hyeon
Jung Mee-Jung
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Abstract
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The antioxidant and anti-diabetes effects were evaluated by the ethanol extracts from Astragalus membranaceus
root classified by years using through DPPH radical scavenging activity, hydroxyl radical (·OH) scavenging activity, total phenolic and flavonoid contents, reducing power activity, α-amylase and α-glucosidase inhibitory activities. IC50 values for DPPH radical scavenging activity of ethanol extract from 6 years old root (749.25μg/mL) was higher than 1 year (1452.67μg/mL) and 3 years old root (1095.61 μg/mL). 6 years old root showed better effects in ·OH scavenging activity (IC50: 10.58 μg/mL), reducing power, total phenolic contents (26.13±0.79 Tanμg/mg, 24.03±0.74 Cat μg/mg) α-amylase (33.33±0.55%) and α-glucosidase inhibitory activity (49.71±1.01%). On the other hand, total flavonoid compound contents were estimated much higher in 1 year old root (44.93±1.35 Que μg/mg, 70.32±2.03 Rut μg/mg) than others. Based on these results, It was suggested that 6 years old root of A. membranaceus has a potential candidate for functional cosmetic and medicine.
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KEYWORD
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Astragalus membranaceus, Antioxidative activity, Ant-diabetic activity, DPPH radical, hydroxyl radical
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